Author
The different degree of plasma protein binding to drugs may have important clinical repercussions on specific diseases or physiological conditions of the human being. The objective of this first international symposium of the Esteve Foundation was to have different experts on drugs and protein binding discuss the biological grounds and the biochemical mechanisms of such binding, as well as their involvement in specific diseases. Both the submissions and the discussions are included in the book Drug-protein binding, edited by Marcus Reidenberg (Cornell University Medical College, New York) and Sergio Erill (Fundación Dr. Antonio Esteve, Barcelona), and published by Praeger Scientific.
| Chapters | ||
| Contributors | [wpdm id=36 type=”btn”] | |
| Preface | MM. Reidenberg / S. Erill | [wpdm id=37 type=”btn”] |
| Contents | [wpdm id=62 type=”btn”] | |
| 1. Introductory remarks | MM. Reidenberg | [wpdm id=39 type=”btn”] |
| 2. Structure of binding sites on albumin | WE. Müller / KJ. Fehske / SAC. Schläfer | [wpdm id=40 type=”btn”] |
| 3. Physico-chemical aspects of ligand binding: pharmacological implications | G. Weber | [wpdm id=41 type=”btn”] |
| 4. The specificity of drug binding sites on human serum albumin | I. Sjöholm | [wpdm id=42 type=”btn”] |
| 5. The study of drug-protein interactions by spin labeling | JL. Holtzman | [wpdm id=43 type=”btn”] |
| 6. Methodological problems in drug-binding studies | H. Kurz | [wpdm id=44 type=”btn”] |
| 7. Lipoprotein binding of drugs | M. Lemaire / S. Urien / E. Albengres / P. Riant / R. Zini / JP. Tillement | [wpdm id=45 type=”btn”] |
| 8. Drug binding to purified orosomucoid influenced by protein purification methods | E. Pike / P. Kierulf / B. Skutenid / J.E. Bredesen / G. Smistad | [wpdm id=46 type=”btn”] |
| 9. Tissue binding of drugs | MH. Bickel | [wpdm id=47 type=”btn”] |
| 10. Drug binding to blood cells | M. Ehrnebo | [wpdm id=48 type=”btn”] |
| 11. Interindividual differences in drug-protein binding | F. Sjòqvist / Y. Koike | [wpdm id=49 type=”btn”] |
| 12. Drug-protein binding in young children | SJ. Yaffe | [wpdm id=56 type=”btn”] |
| 13. Drug-protein binding in old age | JG. Kelly / K. O\’Malley | [wpdm id=50 type=”btn”] |
| 14. Drug-protein binding in renal disease | I. Odar-Cederlöf | [wpdm id=52 type=”btn”] |
| 15. Drug-protein binding in liver disease and in patients with hypoalbuminemia | R. Gugler / JC. Jensen | [wpdm id=52 type=”btn”] |
| 16. Inflammation and Alpha1-acid glycoprotein: effect on drug binding | PKM. Lunde / E. Pike / JE. Bredesen | [wpdm id=53 type=”btn”] |
| 17. Posttranslational changes of albumin as a cause of altered drug-plasma protein binding | S. Erill / R. Calvo | [wpdm id=58 type=”btn”] |
| 18. Fatty acids modulation of drug binding to plasma proteins | CA. Naranjo / EM. Sellers | [wpdm id=54 type=”btn”] |
| 19. Drug displacement interactions: a case study of the phenylbutazone-warfarin interaction | EM. Sellers | [wpdm id=55 type=”btn”] |
| 20. Drug-plasma protein binding and apparent volume of distribution: a complex relationship | P. du Souich / R. Babini | [wpdm id=57 type=”btn”] |
| 21. Plasma binding and hepatic drug elimination | GR. Wilkinson | [wpdm id=59 type=”btn”] |
| 22. Effect of protein binding on the pharmacologic activity of drugs as exemplified by Warfarin | G. Levy | [wpdm id=61 type=”btn”] |
| 23. Protein binding of drugs, drug enantiomers, active drug metabolites and therapeutic drug monitoring | DE. Drayer | [wpdm id=60 type=”btn”] |
| Credits | [wpdm id=63 type=”btn”] | |
- 11. Interindividual differences in drug-protein binding
- F. Sjòqvist / Y. Koike
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- Credits
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- 23. Protein binding of drugs, drug enantiomers, active drug metabolites and therapeutic drug monitoring
- DE. Drayer
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- 22. Effect of protein binding on the pharmacologic activity of drugs as exemplified by Warfarin
- G. Levy
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- 21. Plasma binding and hepatic drug elimination
- GR. Wilkinson
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- 20. Drug-plasma protein binding and apparent volume of distribution: a complex relationship
- P. du Souich / R. Babini
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- 19. Drug displacement interactions: a case study of the phenylbutazone-warfarin interaction
- EM. Sellers
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- 18. Fatty acids modulation of drug binding to plasma proteins
- CA. Naranjo / EM. Sellers
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- 17. Posttranslational changes of albumin as a cause of altered drug-plasma protein binding
- S. Erill / R. Calvo
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- 16. Inflammation and Alpha1-acid glycoprotein: effect on drug binding
- PKM. Lunde / E. Pike / JE. Bredesen
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- 15. Drug-protein binding in liver disease and in patients with hypoalbuminemia
- R. Gugler / JC. Jensen
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- 14. Drug-protein binding in renal disease
- I. Odar-Cederlöf
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- 13. Drug-protein binding in old age
- JG. Kelly / K. O'Malley
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- 12. Drug-protein binding in young children
- SJ. Yaffe
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- Contributors
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- 10. Drug binding to blood cells
- M. Ehrnebo
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- 9. Tissue binding of drugs
- MH. Bickel
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- 8. Drug binding to purified orosomucoid influenced by protein purification methods
- E. Pike / P. Kierulf / B. Skutenid / J.E. Bredesen / G. Smistad
- Download
- 7. Lipoprotein binding of drugs
- M. Lemaire / S. Urien / E. Albengres / P. Riant / R. Zini / JP. Tillement
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- 6. Methodological problems in drug-binding studies
- H. Kurz
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- 5. The study of drug-protein interactions by spin labeling
- JL. Holtzman
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- 4. The specificity of drug binding sites on human serum albumin
- I. Sjöholm
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- 3. Physico-chemical aspects of ligand binding: pharmacological implications
- G. Weber
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- 2. Structure of binding sites on albumin
- WE. Müller / KJ. Fehske / SAC. Schläfer
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- 1. Introductory remarks
- MM. Reidenberg
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- Drug-protein binding Contents
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- Drug-protein binding Preface
- MM. Reidenberg / S. Erill
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