Autor
El diferente grado de fijación de los fármacos a las proteínas del plasma puede tener repercusiones clínicas importantes en determinadas enfermedades o estados fisiológicos del ser humano. El objetivo de este primer simposio internacional de la Fundación Dr. Antonio Esteve fue reunir diversos expertos sobre fármacos y su fijación proteica, a fin de discutir las bases biológicas y los mecanismos bioquímicos de esta fijación y su implicación en determinadas enfermedades. Tanto las ponencias como las discusiones aparecen en este libro Drug-protein binding editado por Marcus Reidenberg (Cornell University Medical College, Nueva York) y Sergio Erill (Fundación Dr. Antonio Esteve, Barcelona)y publicado por Praeger Scientific.
| Capítulos | ||
| Contributors | [wpdm id=36 type=”btn”] | |
| Preface | MM. Reidenberg / S. Erill | [wpdm id=37 type=”btn”] |
| Contents | [wpdm id=62 type=”btn”] | |
| 1. Introductory remarks | MM. Reidenberg | [wpdm id=39 type=”btn”] |
| 2. Structure of binding sites on albumin | WE. Müller / KJ. Fehske / SAC. Schläfer | [wpdm id=40 type=”btn”] |
| 3. Physico-chemical aspects of ligand binding: pharmacological implications | G. Weber | [wpdm id=41 type=”btn”] |
| 4. The specificity of drug binding sites on human serum albumin | I. Sjöholm | [wpdm id=42 type=”btn”] |
| 5. The study of drug-protein interactions by spin labeling | JL. Holtzman | [wpdm id=43 type=”btn”] |
| 6. Methodological problems in drug-binding studies | H. Kurz | [wpdm id=44 type=”btn”] |
| 7. Lipoprotein binding of drugs | M. Lemaire / S. Urien / E. Albengres / P. Riant / R. Zini / JP. Tillement | [wpdm id=45 type=”btn”] |
| 8. Drug binding to purified orosomucoid influenced by protein purification methods | E. Pike / P. Kierulf / B. Skutenid / J.E. Bredesen / G. Smistad | [wpdm id=46 type=”btn”] |
| 9. Tissue binding of drugs | MH. Bickel | [wpdm id=47 type=”btn”] |
| 10. Drug binding to blood cells | M. Ehrnebo | [wpdm id=48 type=”btn”] |
| 11. Interindividual differences in drug-protein binding | F. Sjòqvist / Y. Koike | [wpdm id=49 type=”btn”] |
| 12. Drug-protein binding in young children | SJ. Yaffe | [wpdm id=56 type=”btn”] |
| 13. Drug-protein binding in old age | JG. Kelly / K. O\’Malley | [wpdm id=50 type=”btn”] |
| 14. Drug-protein binding in renal disease | I. Odar-Cederlöf | [wpdm id=52 type=”btn”] |
| 15. Drug-protein binding in liver disease and in patients with hypoalbuminemia | R. Gugler / JC. Jensen | [wpdm id=52 type=”btn”] |
| 16. Inflammation and Alpha1-acid glycoprotein: effect on drug binding | PKM. Lunde / E. Pike / JE. Bredesen | [wpdm id=53 type=”btn”] |
| 17. Posttranslational changes of albumin as a cause of altered drug-plasma protein binding | S. Erill / R. Calvo | [wpdm id=58 type=”btn”] |
| 18. Fatty acids modulation of drug binding to plasma proteins | CA. Naranjo / EM. Sellers | [wpdm id=54 type=”btn”] |
| 19. Drug displacement interactions: a case study of the phenylbutazone-warfarin interaction | EM. Sellers | [wpdm id=55 type=”btn”] |
| 20. Drug-plasma protein binding and apparent volume of distribution: a complex relationship | P. du Souich / R. Babini | [wpdm id=57 type=”btn”] |
| 21. Plasma binding and hepatic drug elimination | GR. Wilkinson | [wpdm id=59 type=”btn”] |
| 22. Effect of protein binding on the pharmacologic activity of drugs as exemplified by Warfarin | G. Levy | [wpdm id=61 type=”btn”] |
| 23. Protein binding of drugs, drug enantiomers, active drug metabolites and therapeutic drug monitoring | DE. Drayer | [wpdm id=60 type=”btn”] |
| Credits | [wpdm id=63 type=”btn”] | |
- 11. Interindividual differences in drug-protein binding
- F. Sjòqvist / Y. Koike
- Descargar
- Credits
- Descargar
- 23. Protein binding of drugs, drug enantiomers, active drug metabolites and therapeutic drug monitoring
- DE. Drayer
- Descargar
- 22. Effect of protein binding on the pharmacologic activity of drugs as exemplified by Warfarin
- G. Levy
- Descargar
- 21. Plasma binding and hepatic drug elimination
- GR. Wilkinson
- Descargar
- 20. Drug-plasma protein binding and apparent volume of distribution: a complex relationship
- P. du Souich / R. Babini
- Descargar
- 19. Drug displacement interactions: a case study of the phenylbutazone-warfarin interaction
- EM. Sellers
- Descargar
- 18. Fatty acids modulation of drug binding to plasma proteins
- CA. Naranjo / EM. Sellers
- Descargar
- 17. Posttranslational changes of albumin as a cause of altered drug-plasma protein binding
- S. Erill / R. Calvo
- Descargar
- 16. Inflammation and Alpha1-acid glycoprotein: effect on drug binding
- PKM. Lunde / E. Pike / JE. Bredesen
- Descargar
- 15. Drug-protein binding in liver disease and in patients with hypoalbuminemia
- R. Gugler / JC. Jensen
- Descargar
- 14. Drug-protein binding in renal disease
- I. Odar-Cederlöf
- Descargar
- 13. Drug-protein binding in old age
- JG. Kelly / K. O'Malley
- Descargar
- 12. Drug-protein binding in young children
- SJ. Yaffe
- Descargar
- Contributors
- Descargar
- 10. Drug binding to blood cells
- M. Ehrnebo
- Descargar
- 9. Tissue binding of drugs
- MH. Bickel
- Descargar
- 8. Drug binding to purified orosomucoid influenced by protein purification methods
- E. Pike / P. Kierulf / B. Skutenid / J.E. Bredesen / G. Smistad
- Descargar
- 7. Lipoprotein binding of drugs
- M. Lemaire / S. Urien / E. Albengres / P. Riant / R. Zini / JP. Tillement
- Descargar
- 6. Methodological problems in drug-binding studies
- H. Kurz
- Descargar
- 5. The study of drug-protein interactions by spin labeling
- JL. Holtzman
- Descargar
- 4. The specificity of drug binding sites on human serum albumin
- I. Sjöholm
- Descargar
- 3. Physico-chemical aspects of ligand binding: pharmacological implications
- G. Weber
- Descargar
- 2. Structure of binding sites on albumin
- WE. Müller / KJ. Fehske / SAC. Schläfer
- Descargar
- 1. Introductory remarks
- MM. Reidenberg
- Descargar
- Drug-protein binding Contents
- Descargar
- Drug-protein binding Preface
- MM. Reidenberg / S. Erill
- Descargar
